冠心病患者血浆Chemerin水平与高同型半胱氨酸血症的相关性

Relationship between plasma chemerin level and hyperhomocysteinemia in patients with coronary heart disease

目的探讨冠心病患者血浆Chemerin水平与高同型半胱氨酸血症(HHcy)的相关性。方法行冠状动脉造影术检查的疑诊冠心病患者152例,根据冠脉造影结果分为:冠心病组98例;非冠心病组54例。另外选取健康体检患者30例为对照组。监测血浆Chemerin水平及同型半胱氨酸(Hcy)浓度,同时测定各组血压及生化指标。结果冠心病组Chemerin、Hcy、肌酐、空腹血糖水平、收缩压均显著高于非冠心病组(P<0.05),且冠心病、非冠心病组上述指标显著高于对照组(P<0.05)。三组HHcy发生率比较差异有统计学意义(P<0.05)。血浆Chemerin与高HHcy发生率呈正相关(r=0.30,P<0.05)。结论血浆Chemerin与HHcy发生率正相关,血浆Chemerin及Hcy水平与冠心病发生相关。

Objective To explore the relationship between plasma chemerin level and hyperhomocysteinemia （HHcy） in patients with coronary heart disease （CHD）. Methods Based on the results of coronary angiography,152 patients with suspected CHD were divided into two groups as CHD group （98 cases） and non-CHD group （54 cases）. Another 30 people underwent physical examination were selected as control group. Plasma chemerin level and Hcy concentration were detected by ELISA;meanwhile,the blood pressure and biochemical indexes were also analyzed. Results Plasma chemerin level and Hcy, creatinine,fasting plasma glucose（FPG） and systolic blood pressure（SBP） in CHD group were significantly higher than those in non-CHD group （P〈0.05）,which were also significantly higher in CHD group and non-CHD group than control group （P〈0.05）.There was also significant difference of occurrence rate of HHcy among 3 groups （P〈0.05）. Plasma chemerin level was positively associated with the incidence of HHcy （P〈0.05）. Conclusion Plasma chemerin level was positively correlated with the occurrence rate of HHcy. Plasma chemerin and Hcy levels were correlated with CHD.