BCRP在浸润性乳腺癌中的表达及其与上皮间质转化相关蛋白的相关性

Expression of BCRP in invasive breast cancer,and its correlation with the epithelial-mesenchymal transition-related protein

目的：探讨乳腺癌耐药蛋白（ BCRP）在浸润性乳腺癌组织中的表达情况及其与上皮间质转化相关蛋白的相关性。方法：采用免疫组织化学方法检测80例浸润性乳腺癌组织、40例癌旁组织、40例乳腺纤维腺瘤组织中BCRP蛋白的表达情况,分析其与临床病理参数的关系,进一步研究BCRP蛋白与上皮性钙黏蛋白、神经性钙黏蛋白的相关性。结果：BCRP蛋白在浸润性乳腺癌中的阳性表达率为57.5%。 BCRP蛋白阳性表达率在组织学分级、淋巴结转移和TNM分期间差异均有统计学意义（P〈0.05～P〈0.01）。 BCRP与HER-2、神经性钙黏蛋白表达均呈正相关关系（P〈0.01）,与上皮性钙黏蛋白呈负相关关系（P〈0.01）。结论：在浸润性乳腺癌中,BCRP蛋白可能与乳腺癌的发生、发展密切有关,同时与上皮间质转化存在一定的相关性。

Objective：To investigate the expression of breast cancer resistance protein（BCRP） in invasive breast cancer,and its correlation with the epithelial-mesenchymal transition-related protein. Methods：The expressions of BCRP in 80 invasive breast cancer tissue specimens, 40 peritumoral tissue specimens and 40 breast fibroadenoma tissue specimens were detected using immunohistochemistry. The relationship between the expression of BCRP and clinical pathological parameters was analyzed, and the correlations of the expression of BCRP with E-cadhein and N-cadhein were investigated. Results：The positive expression rate of BCRP in invasive breast cancer tissue was 57. 5%. The differences of the positive expression rate of BCRP in different histological grade, lymph node metastasis and TNM staging were not statistically significant（P〈0. 05 to P〈 0. 01）. The expression rate of BCRP were positively and negatively with the expressions of HER-2 and N-cadherin,and E-cadherin,respectively（P〈0. 01）. Conclusions：The BCRP may be involved in the occurrence and development in invasive breast cancer,and which is correlation with EMT.