贝蒌散结舒乳汤治疗乳腺腺病之痰瘀互结型临床研究—附120例临床观察报告

Clinical research of Beilou Sanjie Shuru decoction in the treatment of breast adenosis of phlegm and blood stasis—120 cases of clinical observation report

目的:观察分析贝蒌散结舒乳汤、乳癖消两种药物治疗乳腺腺病之痰瘀互结型的临床效果。方法:选取山东省威海市中医院乳腺外科及妇科门诊患者共120例为研究对象。该120病例均同时符合西医学乳腺增生症的诊断标准及中医诊断中痰瘀互结型的辨证分型,并需排除其他乳腺性、恶性肿瘤疾病。将120例患者随机分为A、B两组,每组60例,分别给予:A组贝蒌散结舒乳汤、B组乳癖消。观察两组患者的临床治疗效果,进行统计学分析。结果:根据中医证候的分级评分、乳房疼痛综合评分及彩色多普勒影像学检查评分分析临床疗效。A组的总有效率为90.0%,B组的总有效率为61.7%。两组进行比较后,P<0.05,因此认为两组临床治疗效果的差异有统计学意义,但对于乳腺腺病之痰瘀互结型的患者,贝蒌散结舒乳汤较乳癖消有明显疗效。结论:贝蒌散结舒乳汤与乳癖消比较,对乳腺腺病之痰瘀互结型的治疗都具有良好的疗效,且后者的不良反应少,因此两药都值得推广应用,但是贝蒌散结舒乳汤较乳癖消有明显疗效。

Objective： To observe and analyze the clinical effects of Beilou Sanjie Shuru decoction and Rupixiao in treating breast adenosis of phlegm and blood stasis. Methods： 120 cases of breast adenosis of phlegm and blood stasis in the breast surgery and gynecology departments of Weihai Hospital of traditional Chinese medicine in Shandong province were selected as the research subjects. These 120 cases were also consistent with the diagnostic criteria of Western medicine disease of Hyperplasia of Mammary Gland（HMG）, and TCM diagnosis of stagnation of phlegm and blood stasis syndrome, and other breast and malignant tumor diseases were excluded. All of these patients were randomly divided into group A and group B. Group A was treated with Beilou Sanjie Shuru decoction and group B received Rupixiao. The clinical effects of two groups were observed and statistically analyzed. Results： TCM syndrome classification score, breast pain comprehensive score and color Doppler imaging examination score were used for the clinical analysis of the curative effect. The total effective rate of group A was 90.0%, and the total effective rate was 61.7% in group B, P 〈 0.05, the difference of clinical treatment effect between two groups was statistically significant. Beilou Sanjie Shuru decoction had more significant effect than Rupixiao in treating breast adenosis ofphlegrn and blood stasis. Conclusions： Both Beilou Sanjie Shuru decoction and Rupixiao had significant effect in treating breast adenosis of phlegm and blood stasis, therefore, both was worthy of clinical popularization and application, but Beilou Sanjie Shuru decoction had less side effect and more significant effect.