探讨基础胰岛素与预混胰岛素治疗2型糖尿病的临床疗效

Clinical effect of basal insulin combined with premixed insulin in treating type 2 diabetes

目的:探究基础胰岛素与预混胰岛素治疗2型糖尿病的临床疗效。方法:选取我院2014年9月—2015年8月收治的124例2型糖尿病患者,经随机抽签分成A组和B组,每组62例。B组,每日2次预混门冬胰岛素30(PM-2),A组每日1次甘精胰岛素,主餐前给予门冬胰岛素注射(G+1),对比两组临床效果。结果:基础胰岛素联合餐前注射、预混胰岛素治疗,能够有效改善患者的血糖。胰岛素的用量、低血糖发生率、体重增加幅度、治疗依从性上G+1,明显优于PM-2,但是改善血糖控制方面,B组的效果较差。结论:预混胰岛素治疗(PM-2)与G+1治疗在低血糖发生率控制上相比,效果稍差。但总体血糖改善效果差异不大,两者均具有良好的应用效果。

Objective： To explore the clinical effect of basal insulin combined with premixed insulin in treating type 2 diabetes. Methods： 124 patients with type 2 diabetes treated in our hospital from September 2014 to August 2015 were selected and randomly divided into group A and group B, with 62 cases in each group. Group B received premixed insulin aspart 30 （PM-2）, twice a day while Group A received insulin glargine and the injection of insulin aspart （G＋1） before the major meal, the clinical effect of two groups was compared. Results： Basal insulin combined with the injection of premixed insulin before the major meal could effectively control the patients blood sugar level. Insulin dosage, incidence of hypoglycemia, weight gain, treatment compliance of Group A （G＋1） were significantly better than that of Group B （PM-2）, Group B had a poorer effect in controlling the blood sugar. Conclusion： PM-2 and G＋1 had a poorer effect in controlling incidence of hypoglycemia. The difference of improving the overall blood sugar was not significant, both of them had good application effect.