MYH9在大肠癌中的表达及临床意义

Expressions and significance of MYH9 in colorectal cancer

目的探讨非肌肉肌球蛋白ⅡA在大肠癌癌组织中的表达及临床意义。方法采用免疫组织化学方法检测MYH9蛋白在90例大肠癌及相应癌旁组织中的表达,探讨MYH9在不同阶段大肠癌中表达及其与临床病理特征的相关性。结果 MYH9蛋白在大肠癌组织中阳性表达强度明显高于癌旁组织(P<0.05)。并且其表达水平与TNM分期、有无淋巴结转移及细胞分化程度显著相关(P<0.05),而与患者的年龄、性别、肿瘤类别无关(P>0.05)。结论 MYH9在大肠癌中表达上调,并且与肿瘤恶性临床病理特征有关。

Objective To establish the expressions and significance of MYH9 in colorectal cancer.Methods The expression of MYH9 were detected in 90 cases colorectal cancer and adjoining colorectal tissues by immunohistochemical method,and the relationship between MYH9 expression and the clinical pathological features were analyzed by Pearson chi-square test.Results MYH9 expression was significantly increased in colorectal cancer than adjoining colorectal tissues（P〈0.05）.Meanwhile,the expression of MYH9 in colorectal cancer was related to different TNM stages,lymphnode metastasis and tumor differentiation（P〈0.05）.But the expression of MYH9 had no relationship with patient＇s age,sex and tumor types（P〉0.05）.Conclusion MYH9 expression was significantly increased in colorectal cancer,and had a closed relationship with the clinical pathological features.