IFN-γ释放试验(TB-IGRA)对维吾尔族患者结核病诊断中价值研究

The diagnosis value of tuberculosis in Uygur patients by TB-IGRA

目的探讨γ-干扰素释放试验(TB-IGRA)在维吾尔族患者中结核病诊断和筛查中的诊断价值。方法分析2015年1月-2016年3月430例在我院接受治疗的疑似结核病患者的临床资料,其中维吾尔族患者226例,列为观察组,其余204例汉族患者设为对照组。结果维吾尔族患者TB-IGRA检测阳性率明显高于对照组,维吾尔族IFN-γ分泌水平均明显高于汉族(P<0.05);吾尔族女性TB-IGRA检测阳性率明显高于维吾尔族男性、汉族女性(P<0.05);维吾尔族20岁至30岁之间患者TB-IGRA检测阳性率明显高于汉族20岁至30岁之间患者TB-IGRA(P<0.05);TB-IGRA检测灵敏度、准确度明显高于痰涂片检测,差异均具有统计学意义(P<0.05)。结论 TB-IGRA检测在灵敏度和准确性明显优于涂片分枝杆菌检测,具有较高的结核病临床诊断价值。

Objective To study the diagnosis value of tuberculosis in Uygur patients by TB-IGRA.Methods Clini-cal data of 430 cases of suspected tuberculosis patients admitted to our hospital from March 2016 to January 2015 were analyzed,including 226 cases of Uygur patients as observation group and 204 cases of Han patients as control group. Results The positive rate of TB-IGRA in the Uygur patients was significantly higher than that in the control group, and the level of IFN-r was significantly higher than that of the Han nationality （P〈0.05）;Uygur women TB-IGRA positive detection rate was significantly higher than that of Uygur male positive rate （P〈0.05）,Uygur women TB-IGRA positive detection rate was significantly higher than that of the positive rate of women of Han nationality （P〈0. 05）;The positive rate of TB-IGRA was significantly higher in the patients between the ages of 20 and 30 was signifi-cantly higher than the Han nationality between the ages of 20 and 30;The detection sensitivity and accuracy of TB-IGRA were significantly higher than that of sputum smear,and the difference was statistically significant （P〈0.05）. Conclusion the sensitivity and accuracy by TB-IGRA detection is significantly better than smear detection of Mycobac-terium tuberculosis,it has a high clinical value of tuberculosis.