NGAL在诊断原发性高血压患者中的临床意义分析

NGAL clinical significance in the diagnosis of patients with essential hypertension in Analysis

目的研究中性粒细胞明胶酶相关脂质运载蛋白(NGAL)在原发性高血压患者的诊断效果及临床意义,为临床提供依据。方法选取2013年1月-2015年12月医院诊治的原发性高血压患者60例,将其设为观察组;选取同期入院健康体检者60例,采用ELISA法测定患者血清、尿NGAL及尿微量清蛋白水平;AU2700全自动生化仪检测血清膀胱抑制素C(CysC)、肌酐水平(Scr)及超敏C反应蛋白(hsCRP),分析NGAL在原发性高血压患者中的诊断效果。结果观察组血NGAL、尿NGAL及尿微量清蛋白水平,显著高于对照组(P<0.05);观察组患者CysC、Scr及hsCRP水平,显著高于对照组(P<0.05)。结论通过测定NGAL诊断原发性高血压患者效果理想,且联合其他生化指标能提高临床确诊率,了解患者病情严重程度,值得推广应用。

Objective To study the effect of NGAL in the diagnosis and clinical significance of patients with essen-tial hypertension,in order to provide the clinical basis.Methods January 2013-60 cases of primary hypertension pa-tients to hospital for treatment in December 2015,and set it in the observation group;select the same period 60 cases of hospitalized healthy,measured by ELISA serum,urine NGAL and trace levels of urinary albumin;AU2700 automatic biochemical analyzer serum inhibin bladder C （CysC）,serum creatinine （Scr）and high-sensitivity C-reactive protein （hsCRP）,analysis of NGAL in patients with essential hypertension diagnostic results.Results The serum NGAL,uri-nary NGAL and urinary microalbumin levels were significantly higher （P〈0.05）;the observation group were CysC, Scr and hsCRP levels were significantly higher （P〈0.05 ）.Conclusion The diagnosis desired effect by measuring NGAL in patients with essential hypertension,and in conj unction with other clinical and biochemical indexes can im-prove the diagnosis rate,understand the severity of the patient＆#39;s condition,should be widely applied.