MTBP与癌症的研究进展

Research progress of MDM2-binding protein in cancer

鼠双微体2癌基因结合蛋白(MDM2-binding protein,MTBP)是鼠双微体2(Murine double minute 2,MDM2)的结合蛋白,并参与调节细胞的代谢、增殖及凋亡等生物学过程。近年来研究发现MTBP在多种恶性肿瘤中出现表达异常,其表达的异常与恶性肿瘤的增殖、侵袭转移、发生、发展及预后关系密切。MTBP可能成为多种恶性肿瘤治疗的潜在靶点。本文将MTBP在恶性肿瘤中的研究做一简要综述。

MDM2-binding protein（MTBP） factor is a binding protein of MDM2,and MDM2 gene and involved in the development of cancer as an important gene,which has been studied for a long time.It has been demonstrated that MTBP could regulate biological processes such as metabolism,growth,and apoptosis of cells.In the past few years,some studies have found that MTBP is down- regulated in variety of malignancies,which is associated with the progression and the prognosis of these tumors.MTBP may be a potential target for the treatment of many kinds of malignant tumors.This paper reviews the research pregressof MDM2- binding protein on cancer.