MUC1和MUC16在胆囊癌中的研究进展

Research progress of MUC1 and MUC16 in gallblader carcinoma

黏蛋白(MUC)是由上皮细胞分泌的一类高分子化、高度糖基化的糖蛋白,广泛存在于呼吸系统、消化系统、泌尿生殖系统的黏膜上皮及其分泌的黏液中。目前研究表明,黏蛋白家族与肿瘤关系密切。其中MUC1(CA153)及MUC16(CA125)已被证实在胆管癌中异常表达,但未明确二者与胆囊癌的发生发展、侵袭转移及判断预后有密切的关系。本文通过对近年来国内外文献进行回顾性分析,对MUC1和MUC16在胆囊癌中的研究进展进行综述。

Mucins（MUC）are secreted by the epithelial cells of polymer,the height of glycosylation glycoprotein,widely existing in the respiratory system,digestive system,urogenital system in the mucosa epithelium and mucus secretion.The resent studies show that sticks are closely associated with tumor protein family.Among them,the sticky protein 1（CA153）and 16 mucins（CA125） has been confirmed that the abnormal expression in the bile duct carcinoma.However,there is unclear relationship between the development,invasion,metastasis and prognosis of gallbladder.Based on the retrospective literature at home and abroad in recent years,the research progress on the sticky protein 1 and mucins 16 in the gallbladder is summarized in the present review.