归肾丸合桃红四物汤加减改善宫腔粘连分离术预后的疗效观察

Curative Observation of Using Guishen Pill Combined with Taohong Siwu Decoction in Improving the Prognosis of Intrauterine Adhesions

目的：观察归肾丸合桃红四物汤加减改善宫腔粘连分离术预后的疗效。方法：选择2012年1月~2013年12月期间在我院宫腔镜检查确诊为中重度宫腔粘连的102例患者,均宫腔镜下行宫腔粘连分离术,并放置宫内节育器。随机分为治疗组和对照两组。对照组给予戊酸雌二醇片2mg Bid po,共计21天,最后10天加用地屈孕酮片10mg Bid,序贯治疗;治疗组在对照组的基础上配合使用归肾丸合桃红四物汤加减。10天为1个疗程,每月随访,连续用药3个月后,治疗组、对照组患者均进行复诊,观察月经的期量色质等情况,并复查宫腔镜,了解宫腔情况,同时取出宫内节育器或重新放置新的宫内节育器。治疗前后对宫腔粘连程度进行评分,并计算治疗有效率,观察副反应状况。结果治疗、对照组患者治疗前后宫内粘连各项评分有所改善,总评分改变有统计学差异。治疗组治疗有效率达93.88%,较对照组88%略优。两组均未出现严重副反应状况。结论归肾丸合桃红四物汤加减对宫腔粘连分离术预后有明显改善作用。

Objective： To investigate the curative effect of using Guishen Pill combined with Taohong Siwu Decoction to improve the prognosis of intrauterine adhesions. Methods： From April 2012 to December 2015 in our hospital during the hysteroscopy examination confirmed the diagnosis in 102 cases of severe intrauterine adhesions were randomly divided into two groups： treatment group and controlled group. The controlled group was treated with estradiol valerate and progesterone capsules for treatment.The treatment group was given Guishen Pill combined with Taohong Siwu Decoction on the basis of the controlled group,10 days for a course of treatment,monthly follow-up,continuous medication after 3months,the two groups of patients were followed up.Before and after the treatment of uterine cavity adhesion score,and calculated the efficiency of treatment,observation of side effects. Results： The intrauterine adhesion score before and after treatment of the two groups were improved,the total score changes had statistically significant differences. The effective rate of the treatment group（ 93. 88%） was slightly better than the controlled group which was 88%. No serious adverse reactions occurred in the two groups. Conclusion： Guishen Pill combined with Taohong Siwu Decoction have significant effect on improving the prognosis of intrauterine adhesions.