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G蛋白偶联受体激酶5与脑老化相关神经退行性疾病的研究进展 被引量:1

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摘要 与脑老化相关的神经退行性疾病主要包括阿尔茨海默病(Alzheimer's disease,AD)和帕金森氏病(Parkinson's disease,PD)。AD是发病率最高的老年神经退行性疾病,临床表现以近记忆障碍为主并逐步发展至全面性痴呆[1]。PD则是继AD之后发病率第二高的神经退行性疾病,
出处 《广东医学》 CAS 北大核心 2016年第23期3626-3629,共4页 Guangdong Medical Journal
基金 国家自然科学基金面上项目(编号:81271214 81571157) 国家青年科学基金项目(编号:81401061)
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  • 1Richter JA, Perry EK, Tomlinson BE. Acetylcholine and choline levels in post-mortem human brain tissue: preliminary observations in Alzheimer's disease. Life Sci 1980, 26: 1683-1689.
  • 2Whitehouse P J, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 1982, 215: 1237- 1239.
  • 3Pakaski M, Kalman J. Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease. Neurochem Int 2008, 53: 103-111.
  • 4Tanzi RE, Bertram L. Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective. Cell 2005, 120: 545-555.
  • 5Hardy JA, Higgins GA. Alzheimer's disease: the amyloid cascade hypothesis. Science 1992, 256: 184-185.
  • 6Koffie RM, Hyman BT, Spires-Jones TL. Alzheimer's disease: synapses gone cold. Mol Neurodegener 2011,6: 63.
  • 7Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001,81:741-766.
  • 8Buee L, Bussiere T, Buee-Scherrer V, Delacourte A, Hof PR. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Brain Res Rev 2000, 33: 95-130.
  • 9Iqbal K, Alonso AD, Gondal JA, Gong CX, Haque N, Khatoon S, et aL Mechanism of neurofibrillary degeneration and pharmacologic therapeutic approach. J Neural Transm Suppl 2000, 59: 213-222.
  • 10Mudher A, Lovestone S. AIzheimer's disease-do tauists and baptists finally shake hands? Trends Neurosci 2002, 25: 22-26.

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