中药代茶饮改善血液透析患者口渴症状的临床研究

Taking Chinese Herbs as Tea Improves Thirsty Symptoms of Hemodialysis Patients

目的:评价中药代茶饮改善血液透析患者口渴症状的有效性和安全性,以期为治疗提供具有中医特色的临床新方案。方法:采用随机对照临床试验方法,将60例辨证为气阴两虚合并湿浊血瘀证的血液透析口渴患者,随机分为观察组和对照组,每组30例,两组均采用西医常规治疗方法,观察组口渴时口服小包装中药饮片代茶饮,对照组口渴时饮水缓解,观察4周。结果:观察组(中药代茶饮组)XQ(口渴程度评分表)评分较治疗前降低,差异有统计学意义(P<0.05);对照组XQ评分较治疗前无变化,差异无统计学意义(P>0.05);治疗后,观察组XQ评分低于对照组,差异有统计学意义(P<0.05);观察组治疗前后口渴严重程度分布差异有统计学意义(P<0.05);平均透析间期体重增加相对值、透析充分性以及血钾,差异无统计学意义(P>0.05);在4周治疗过程中,观察组平均透析间期体重增长的均值±标准差中的均值呈下降趋势,而对照组则无明显变化趋势。结论:中药代茶饮可有效改善血透患者的口渴症状;可减轻口渴程度;平均透析间期体重增加相对值有下降趋势;对于血透患者的血钾、透析充分性无明显影响。

Objective：To observe and evaluate the efficacy and safety of taking Chinese herbs as tea to improve thirsty symptoms of hemodialysis patients so as to provide the clinical new solutions with TCM characteristics. Methods ： By using the randomized controlled method,60 cases from Wangjing Hospital of CATCM,with syndrome types of qiyin deficiency complicated with blood stasis and damp,were randomly divided into observation group and control group. The two groups adopted the conventional western medicine treatment and the observation group took Chinese herbs as tea when they were thirsty. The control group took water when they were thirsty,observing for 4 weeks. Results ：The observation group＇s XQ （xerostomia questionnaire thirsty） degree was reduced and the difference was statistically significant （ P 〈 0. 05 ）. There was no change in XQ score of the control group and there was no statistically significant difference （P 〉 0. 05 ）. After treatment, the XQ score of observation group was lower than the control group＇s and the difference was statistically significant （P 〈 0. 05 ）. After treatment ,the observation group＇s thirsty severity distribution was statistically significant （P 〈 0. 05 ）. After treatment, the average interdialysis weight gain, dialysis adequacy and potassium had no statistically significant difference （ P 〉 0. 05 ）. Around in the course of treatment, the average interdialysis weight gain of observation group was on the decline while the control group＇s had no obvious change trend. Conclusion：Taking Chinese herbs as tea can effectively relieve the symptoms of hemodialysis patients＇ thirst and can reduce the thirst degree, make the average interdialysis weight gain relatively decline. For hemodialysis patients, there is no significant effect on potassium and dialysis adequacy.