柴胡疏肝汤加味对难治性癫痫的影响及疗效相关因素研究

Effect of Chaihu Shugan Decotion for Intractable Epilepsy and Curative Effect of Related Factors

目的:探讨柴胡疏肝汤加味对难治性癫痫疗效及影响其临床疗效的相关性因素。方法:将难治性癫痫患者随机分为两组:对照组予常规治疗;治疗组在常规治疗的基础上予柴胡疏肝汤加味治疗,采集患者年龄、发病频率、依从性等资料,观察两组治疗前后发作频率变化,采用Logistic回归模型对难治性癫痫患者的相关因素进行分析。结果:治疗组改善发作频率方面优于对照组(P<0.05);Logistic回归分析结果显示:年龄、依从性、中医证候、病程、发作频率、药物治疗、发作类型与难治性癫痫疗效有关(P<0.05)。依从性、药物治疗是影响疗效的重要因素(OR:25.303、12.941)。结论:柴胡疏肝汤加味能减少发作频率,同时关注与疗效相关的因素,有助于提高疗效。

Objective ： To study effect of Chaihu Shugan Decotion for intractable epilepsy and related factors of curative effect. Methods：Patients with intractable epilepsy were randomly divided into two groups. Control group used the conventional treatment. The treatment group on the basis of routine therapy added Chaihu Shugan Decotion. We collected patients age, frequency and compliance and observed the seizure frequency change before and after treatment in both groups. By using Logistic regression model,the related factors in patients with refractory epilepsy were analyzed. Results ： Treatment group improved the seizure frequency which was better than that in control group （ P 〈 0. 05 ）. Logistic regression analysis resuhs showed that age, compliance, TCM symptoms, duration, seizure frequency, drug therapy and seizure types were associated with the curative effect on refractory epilepsy （P 〈0. 05）. Compliance and the drug therapy are the important factors that affect the curative effect（ OR：25. 303,25. 303 ）.Conclusion：Chaihu Shugan I）ecotion can reduce the seizure frequency, at the same time, focus on related factors, and can improve curative effect.