舌苔形成相关蛋白的研究进展

Overview of Related Proteins Associated with Tongue Coating Formation

舌苔是人体的重要生理产物,舌诊亦是中医四诊中的关键环节,正逐步受到中西医学者广泛关注。在中医理论中,舌苔由胃气而生;而现代医学研究中,舌苔的差异性与舌上皮细胞的增殖与凋亡相关、与蛋白的表达调控同样相关。目前关注较多的五种舌苔调节蛋白,分别是表皮生长因子(EGF)、上皮型钙黏蛋白(E-cad)、转化生长因子-α(TGF-α)、凋亡相关基因bax、fas、TGF-β3和细胞间黏附分子-1(CD54或ICAM-1),文章综述了它们对于舌苔厚薄以及颜色的影响,以及舌苔形成相关调节蛋白的未来前景展望。

Tongue coating is one of the important physical products of the body. Tongue diagnosis is the key link in four diag- nosis in traditional Chinese medicine. Regardless of race and nationality, tongue coating was significant difference in different diseases, and gradually got attention by the traditional Chinese and western scholars. In the theory of traditional Chinese medicine, tongue coating is generated by the stomach. While in the modem medicine, formation and apoptosis of the tongue coating research mainly focused on the flora of the tongue coating and the related proteins associated with tongue coating formation. The author summed up the current focus on five kinds of tongue coating regulatory proteins, EGF, E - cad, TGF - alpha, bax, fas, apoptosis related gene TGF - B3 and CD54.