甲状腺结节性疾病与碘营养水平关系的临床研究

The clinical study on thyroid nodule correlated with urine supplement level

目的:探讨广东惠州地区甲状腺结节性疾病发病与尿碘含量的关系,为该地区甲状腺疾病患者科学补碘提供依据。方法:选取2013年至2015年惠州市第一人民医院和惠州市中心人民医院收治的甲状腺结节性疾病住院患者200例(结节性甲状腺肿55例,慢性淋巴细胞性甲状腺炎17例,甲状腺乳头状癌128例),并选取同期体检中心的甲状腺正常人群50例为对照组,采集空腹晨尿,测定尿碘含量。结果:甲状腺乳头状癌的尿碘中位数为182.5μg/L,高于健康人群组(133.5μg/L)和良性甲状腺结节组(133μg/L),差异有统计学意义(P<0.05)。结论:广东惠州地区甲状腺乳头状癌患者摄碘量高于甲状腺良性结节患者和一般健康人群,但甲状腺癌的发病与高碘摄入是否有直接关系仍有待进一步研究明确。

Objective：To investigate the association of thyroid nodule and urine iodine level in Huizhou region and provide the evidence of iodine supplement of thyroid nodule patients in this region. Methods： In this study, there were 200 patients with thyroid nodule,including 55 patients with nodular goiter, 17 patients with chronic lymphocytic thyroiditis, 128 patients with papillary thyroid carcinoma, and 50 patients without thyroid nodule as the control group. All cases were detected for urine iodine concentration. Results： The median urine iodine of papillary thyroid carcinoma （ 182.5 μg/L） was higher than that of control cases （ 133.5 μg/L） and benign nodule cases （ 133 μg/L） （ P 〈 0.05 ）. Conclusion：The average urinary iodine content of the papillary thyroid carcinoma in Huizhou region are generally higher than that of patients with benign nodule and healthy people, however, the relationship between thyroid carci- noma and excessive iodine intake need further study.