S-N-乙基-2-氨甲基吡咯烷的合成研究进展

The Synthesis Development of(S)-(1-Ethylpyrrolidin-2-yl)methanamine

(S)-N-乙基-2-氨甲基吡咯烷作为左旋舒必利与舒托必利合成的必要起始原料,具有潜在的广阔市场。综述了(S)-N-乙基-2-氨甲基吡咯烷的几种具有代表性的合成方法,并对其进行了分析评价。

（S）-（1-ethylpyrrolidin-2-yl） methanamine is an important synthetic intermediate of Levosulpiride and Sultopride, so that it has a broad market prospects. This article summarizes some representative synthetic methods of（S）-（1-ethylpyrrolidin-2-yl） methanamine and reviewes the advantages and disadvantages of these methods.