藏药七十味珍珠丸的大鼠急性毒性实验研究

Study on the acute toxicity of Tibetan medicine Rannasangpei Pills in rats

目的研究七十味珍珠丸的急性毒性,为临床合理用药提供参考。方法大鼠在24 h内一次性灌胃给予最大剂量10 g/kg的七十味珍珠丸混悬液,观察其在14 d内所产生的毒性反应(死亡、中毒症状)及其严重程度、恢复情况、延迟反应等。结果未见动物死亡、中毒症状和肉眼可见的脏器异常,体重和饲料消耗量无明显变化,但部分血细胞指标(红细胞系、白细胞系)和血液生化学指标(尿素氮、葡萄糖、总蛋白和白蛋白)出现异常。结论大鼠经口给予七十味珍珠丸的最大给药量为10 g/kg,为成人日用剂量的600倍,安全性良好,但在临床应用时应监测血常规和血液生化学指标。

Objective To study the acute toxicity of Rannasangpei Pills, provide reference for clinical rational drug use. Methods The maximum dose of Rannasangpei Pills suspension liquid 10 g/kg was supplied to the rats by gavage for one-time within 24 h, the toxic effects （death, poisoning symptoms） and its severity within 14 days, the recovery, de- layed reaction and other indexes were observed. Results There was no abnormal animal death, poisoning symptoms and abnormal organs visible to the naked eye viscera, and body weight and feed consumption had no obvious changes, but some blood indexes （red blood cells, white blood cells） and blood biochemical indexes （urea nitrogen, glucose, total protein and albumin） had abnormalities. Conclusion The maximum dose of Rannasangpei Pills supplied to the rats through mouth is 10 g/kg, which is 600 times of daily doses of adults, the security is good, but in clinical application, it is necessary to monitor the blood routine and blood biochemistry indexes.