马来酸桂哌齐特治疗糖尿病肾病的临床观察

Clinical Observation on Cinepazide Maleate Injection for Treatment of Diabetic Nephropathy

目的观察马来酸桂哌齐特注射液对糖尿病肾病患者24h尿微量蛋白的影响。方法将57例糖尿病肾病患者随机分为治疗组30例,对照组27例,两组患者根据24h尿微量蛋白分为A组(早期糖尿病肾病组)和B组(临床糖尿病肾病组)。两组患者控制血糖、血压、血脂的治疗方法不变,治疗组加用静脉滴注马来酸桂哌齐特注射液320mg每日1次连续14天,对照组不给上述治疗。结果治疗A组(早期肾病组)与B组(临床肾病组)治疗后,24h尿微量蛋白均较治疗前明显降低;与正常对照组相比明显降低,差异有统计学意义(P<0.05)。结论马来酸桂哌齐特可减少糖尿病肾病患者的尿蛋白。

Objective To investigate effects of Cinepazide Maleate injection on the 24 - hour urine microalbumin in patients with di-abetic nephropathy. Methods Fifty seven patients with diabetic nephropathy were randomly divided into two groups ：treatment group of 30 patients and control group of 27 patients. Based on 24 - hour urinary microalbumin, patients were divided into group A （ early diabetic ne- phropathy） and group B （clinical diabetic nephropathy）. Treatment of two groups of patients were the same in control of blood sugar, blood pressure and blood lipids. The treatment group was treated with intravenous drip of Cinepazide Maleate injection 320mg, once a day, for 14 consecutive days. The control group was not treated with the above treatment. Results After treatment, 24 - hour urinary mi- croalbumin was significantly lower than before treatment in group A （ early diabetic nephropathy） and group B （ clinical diabetic nephropa- thy, and significantly reduced compared with control group. The difference was obvious. Conclusion Maleate cinepazide injection can re- duce 24h urinary microalbumin in patients with diabetic nephropathy.