淫羊藿苷促进间充质干细胞成骨分化:为治疗骨缺损提供一个良好的方向

Icariin promotes the osteogenic differentiation of mesenchymal stem cells: a good candidate for bone defect repair

背景:近年来研究表明,淫羊藿苷能够促进间充质干细胞成骨分化,是一种良好的骨性诱导因子,给骨缺损的治疗提供了新的希望。目的:综述近年来淫羊藿苷对骨组织代谢的药理作用及对间充质干细胞成骨分化影响的研究成果。方法:由第一作者用中国知网数据库和PubMed数据库,检索词分别为"淫羊藿苷;干细胞;成骨"和"icariin,stem cell,osteogenesis",语言分别设定为中文和英文。纳入与"淫羊藿苷、干细胞、成骨"相关的研究。共检索到754篇文章,按纳入和排除标准文献进行筛选,共纳入41篇文章进行综述分析。结果与结论:淫羊藿苷是中国传统中药淫羊藿的主要成分,能够促进骨髓间充质干细胞成骨分化,是一种良好的骨性营养因子。近年来研究表明,淫羊藿苷亦可促进脂肪、脐带以及牙周膜等组织来源的间充质干细胞成骨分化,但是这类研究尚少。目前各间充质干细胞成骨实验效果欠佳,良好的骨性营养因子促进间充质干细胞体内成骨是一种较好的解决方法。因此,淫羊藿苷促进间充质干细胞成骨将可能为治疗骨缺损提供一个良好的方向。

BACKGROUND：Recent studies have shown that icari n is a good bone-inducing factor that can promote the osteogenic differentiation of mesenchymal stem cel s, providing a new hope for the treatment of bone defects. OBJECTIVE：To review research achievements in pharmacological effects of icari n effects on bone tissue metabolism as wel as its effect to promote osteogenic differentiation of mesenchymal stem cel s. METHODS：The first author retrieved CNKI and PubMed databases for relevant Chinese and English literatures using keywords of“icariin, stem cell, osteogenesis”, respectively. Articles regarding icariin, stem cells, osteogenesis were included, and repetitive studies were excluded. Totally 754 articles were retrieved initially. In accordance with inclusion and exclusion criteria, 41 articles were included in result analysis. RESULTS AND CONCLUSION：As the main ingredient of Herba epimedi , icari n functions as a good osteogenetic growth factor to promote the osteogenic differentiation of bone marrow mesenchymal stem cel s. In recent years, icari n has been shown to promote adipose-, umbilical cord-, and periodontal ligament tissue-derived mesenchymal stem cel s to differentiate into osteoblasts. But such studies are less reported. Until now, mesenchymal stem cel s stil exhibit unsatisfactory osteogenic ability in in vivo experiments. Given this, osteogenetic growth factors contribute to the osteogenic differentiation of mesenchymal stem cel s. Therefore, the use of icari n is expected to provide a good strategy for bone defect repair.