TiO_2纳米管对种植体周细胞影响的研究进展

Research process of the effect of titanium dioxide nanotubes on peri-implant cells

背景:与光滑的钛表面相比,TiO_2纳米管可为细胞在材料表面的早期黏附提供有利环境。目的:综述TiO_2纳米管对种植体周组织细胞影响的研究进展。方法:应用计算机检索CNKI、万方、维普及PubMed数据库1990年至2016年的相关文献,检索关键词为"TiO_2纳米管,二氧化钛纳米管,种植体,TiO_2 nanotubes implant,TiO_2 nanotubes cell"。结果与结论:TiO_2纳米管对种植体周细胞行为产生影响的因素,主要包括TiO_2纳米管的管状形貌、纳米管尺寸大小、TiO_2晶型结构、表面化学成分、表面粗糙度及表面亲水性和自由能。TiO_2纳米管对细胞的影响因素有管径依赖性,同时也与细胞类型有关,不同的细胞类型有不同的合适管径,以促进细胞在材料表面的黏附、增殖及分化。因此有必要针对相应的组织细胞筛选出最佳尺寸的纳米管,以便适合其在不同生物医学方面的应用。

BACKGROUND：Compared with the titanium with smooth surface, TiO2 nanotubes are more beneficial for the early cel adhesion. OBJECTIVE：To review the research progress of the effect of TiO2 nanotubes on peri-implant cel s. METHODS：A computer-based retrieval of CNKI, CqVip, WanFang and PubMed databases was performed for pertinent literatures published between 1990 to 2016, using the Chinese keywords of“TiO2 nanotubes or titanium dioxide nanotubes and implant”, and English keywords of“TiO2 nanotubes implant, Tio2 nanotubes cel”. RESULTS AND CONCLUSION：The main factors that TiO2 nanotubes affect the peri-implant cel behaviors include the tubular morphology, size, TiO2 crystal structure, as wel as surface chemical compositions, roughness and hydrophilicity and free energy. The influence factors of TiO2 nanotubes for cel s are not only related to the tube diameter, but also associated with cel types. Different cel types hold different diameters suitable for the cel adhesion, proliferation and differentiation on the material surface. Therefore, it is advisable to select the best nanotube size for different tissues and cel s applied in different biomedical fields.