阿托伐他汀对冠脉粥样斑块和血管内皮功能的影响

The Influence of Atorvastatin on Coronary Plaque and Vascular Endothelial Function

目的:通过阿托伐他汀在不稳定型心绞痛患者中的应用,观察其对血脂、血管内皮生长因子(VEGF)和一氧化氮(NO)的影响。方法:选择不稳定型心绞痛患者36例,所有患者在常规治疗基础上,均口服阿托伐他汀40 mg/d,连用8周后,检测血清血脂、VEGF和NO水平,比较治疗前后的变化。结果:阿托伐他汀治疗8周后患者TC、LDL-C、TG水平较治疗前明显降低,差异有统计学意义(P<0.01);HDC-C、VEGF和NO水平较治疗前明显升高,差异有统计学意义(P<0.01)。结论:阿托伐他汀在不稳定型心绞痛治疗中,不仅具有降脂作用,更重要的是能稳定粥样斑块及对血管内皮功能的改善和保护作用。

Objective： To observe the effect on blood lipids, vascular endothelial growth factor（VEGF） and nitric oxide（NO） by the application of Atorvastatin in patients with unstable anglna.Method： 36 patients with unstable angina were selected.In conventional treatment, all patients were oral Atorvastatin 40 mg/d. the serum lipids, VEGF and NO levels were detected in patients after they last 8 weeks.Result： After Atorvastatin treatment for 8 weeks, the values in patients with TC, LDL-C, TG had been significantly reduced compared with that before treatment, and the values in patients with HDC-C, VEGF and NO had been significantly increased compared with that before treatment.The differences were statistically significant（P〈0.01）.Conclusion： In the treatment of unstable angina pectoris, Atorvastatln in the treatment of unstable angina, not only has a lipid-lowerlng effect, more importantly, it has a stable plaque, improvement and the protective effect on vascular endothelial function.