胰腺神经内分泌肿瘤的诊治难点及对策

Pancreatic neuroendocrine tumor： diagnosis and treatment

胰腺神经内分泌肿瘤（pancreatic neuroendocrine tumor，p—NETs）的发病率逐年提高。作为一种恶性肿瘤，它对人类健康的威胁越来越大。但和胰腺癌这类高度恶性的胰腺肿瘤相比，p—NETs生长速度较慢，早期诊断、早期治疗可达到较好的临床效果。然而目前对p-NETs的认识还有待提高。无论是临床诊断标记物，还是影像学检查方法，都缺乏精准诊断的检查靶点。在临床分期及疾病分级方面，同样存在很大争议。而作为最有效的治疗手段-手术治疗，在手术时机、手术方式、手术范围及术后药物治疗等方面均有待研究。本文针对上诉问题，结合我们的实践经验及研究结果进行简要论述。

Pancreatic neuroendocrine tumor （p-NET） is a kind of neoplasm originating from neuroendocrine cell of pancreas. The morbidity of p-NET increased 5 times in the past 40 years and threatened people＇s life. However, the key points of diagnosis and treatment for p-NET are still unclear. There were no special and easy blood tests or imaging scanning for p-NET. The TNM classification remains controversial. Surgery is the most effective method to cure p-NET. But we still need to clarify which is the best time or method for surgery. In this review, we try to answer above questions based on our experiences and studies.