XIAP和caspase-9在尖锐湿疣组织中的表达

The expression of XIAP and caspase-9 in condyloma acuminatum

目的:检测XIAP和caspase-9在CA组织中的表达。方法:采用免疫组化方法分别检测72例CA组织和20例正常包皮组织中XIAP和caspase-9蛋白的表达。结果:CA组织中XIAP蛋白的阳性表达率(56.94%)高于对照组(15.00%),其差别有统计学意义(P<0.05);而caspase-9蛋白的阳性表达率(37.50%)较对照组(70.00%)低,其差别亦有统计学意义(P<0.05)。两种蛋白在CA组织中的表达呈负相关(r=-0.83,P<0.05)。结论:XIAP抑制caspase-9的活性和表达,两者共同参与CA的发病过程。

Objective： To detect the expression of XIAP and caspase-9 in condyloma acuminatum. Methods： The immunohistochemistry method was used to detect the expression of XIAP and caspase-9 in the tissues of 72 patients with condyloma acuminatum and prepuce tissues of 20 healthy persons. Results ： The positive rate of XIAP protein in condyloma acuminatum was significantly higher than that in normal prepuces （56.94% vs 15%, P〈0.05）, while the positive rate of caspase-9 protein in condyloma acuminatum was lower than that in normal prepuces （37.5% vs 70%, P〈0.05）. There was a negative correlation between the expression of XIAP and caspase-9 （r=-0.83 P〈0.05）. Conclusion： XIAP may promote the development of condyloma acuminatum by inhibiting the activity of caspase-9. The abnormal expression of XIAP and caspase-9 may be involved in the progression of condyloma acuminatum.