中国汉族大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感无相关性

Lack of association between GLCCI1 variant and glucocorticoid sensitivity in Chinese patients with bullous diseases

目的:应用基因分型技术分析中国汉族种群大疱性皮肤病GLCCI1变异体与糖皮质激素不敏感的相关性。方法:将187例大疱性皮肤病患者根据控制病情所需糖皮质激素用量分为实验组(糖皮质激素量≤60 mg,n=129)与对照组(糖皮质激素量≥150 mg,n=58),应用Taqman genotyping技术对研究对象进行位于GLCCI1基因的SNP rs37973基因分型,数据资料应用PLINK软件进行logistic回归分析。结果:未发现GLCCI1基因的SNP rs37973与中国汉族种群大疱性皮肤病中糖皮质激素不敏感存在显著相关性(P=0.7881,OR=1.062)。结论:GLCCI1变异体与中国汉族种群大疱性皮肤病糖皮质激素不敏感无显著相关。

Objective：To investigate the association between GLCCI1 gene and GC sensitivity in Chinese patients with bullous diseases. Methods：A total of 187 subjects were divided into GC-sensitive group （ control dose ≤60 mg, n=129 ） and GC-insensitive group （ control dose ≥150 mg, n=58 ） . Single SNP （ rs37973） was genotyped with TaqMan SNP Genotyping Assay Kit on the GeneAmp 7900 Sequence Detection System using specific TaqMan probes. The statistical analysis was performed using logistic regression in PLINK. Results：We failed to detect rs37973 variation in the patients with GC-insensitive bullous diseases （P=0.7881, odds ratio=1.062）. Conclusion： There is no association between GLCCI1 and glucocorticoids sensitivity in Chinese patients with bullous diseases.