普米克令舒雾化吸入与甲基泼尼松龙静脉注射治疗COPD急性发作疗效的比较

Comparison of the Effects of Pulmicort Respules Inhalation and Intravenous Injection of Methyl Prednisolone to Treat the Acute Episode of COPD

目的:普米克令舒雾化吸入与甲基泼尼松龙静脉注射治疗COPD急性发作疗效的比较。方法:选择100例COPD急性发作患者,随机分为观察组与对照组各50例,其中对照组给予甲基泼尼松龙静脉注射治疗,观察组给予普米克令舒雾化吸入治疗,比较两组患者治疗有效率、治疗前后血气分析、肺功能及不良反应发生率。结果:1观察组治疗后有效率低于对照组(P<0.05);2观察组治疗后FVC、FEV1改善率低于对照组(P<0.05);3观察组治疗后PaCO_2、PaO_2、SaO_2、pH改善率优于对照组(P<0.05);4观察组不良反应发生率明显低于对照组(P<0.05)。结论:普米克令舒雾化吸入与甲基泼尼松龙静脉注射对慢性阻塞性疾病急性发作患者治疗均有显著疗效,普米克令舒雾化吸入后全身不良反应发生率低,可作为全身糖皮质激素治疗COPD急性发作的替代治疗。

Objective：To compare the curative effect of Pulmicort Respules inhalation and intravenous injection of methyl prednisolone to treat the acute episode of chronic obstructive pulmonary disease（COPD）.Methods：100cases of patients with acute episode of COPD were randomly divided into trial group and control group with 50 cases in each group,the control group was given intravenous methyl prednisolone while the trial group was treated with Pulmicort Respules inhalation,to compare the efficiency of the two kinds of treatment between both groups.The blood gas index,respiratory function and adverse reactions before and after treatment were evaluated.Results：1The efficiency of the trial group was significantly higher than that of the control group（P〈0.05）;2After treatment,The improvement rate of FVC、FEV1in the trail group was lower than that of the control group（P〈0.05）;348hafter treatment,The improvementrate of PaCO_2、PaO_2、SaO_2,pH in the trial group was lower than that of the control group（P〈0.05）;（4）The incidence of adverse reaction in the trail group was significantly lower than that of the control group（P〈0.05）.Conclusion：Both of Pulmicort Respules and intravenous methyl prednisolone show a significant effect in the treatment of patients with acute episode of COPD.But Pulmicort Respules inhalation shows less adverse reactions,and it can be used as a replacement therapy for systemic glucocorticoid treatment of acute episode of COPD.