成人与少儿慢性胃炎患者幽门螺杆菌感染与根除相关因素分析

Analysis of Helicobacter pylori infection and eradication for adults and children pa-tients with chronic gastritis

目的调查分析成人与少儿慢性胃炎患者幽门螺杆菌（HP）感染与根除情况及影响因素，为根除治疗提供有利依据。方法通过13C一呼气试验调查856例成人与920例少儿慢性胃炎患者HP感染与根除情况，针对生活中常见的饮食生活习惯自制问卷调查，对调查结果进行分析。结果慢性胃炎患者中HP感染率：成人组60．75％，少儿组41．74％，成人明显高于少儿（P〈0．01）。两组中HP阳性患者均在未独立餐具用餐、洗漱用具不分开、同住人员有HP感染或胃病史三方面及成人在吸烟、饮酒、辛辣饮食三方面，少儿在喜甜食、喜生冷饮食两方面高于阴性组（均P〈0．05）。在严格遵医服药的HP阳性患者中，成人组在未独立餐具用餐、吸烟、饮酒、辛辣饮食四方面不良生活方式率明显高于少儿组（均P〈0．01）。HP根除率：成人组69．84％，少儿组86．20％，成人明显低于少儿（P〈0．01）。结论慢性胃炎患者中，HP感染率成人明显高于少儿。常见的不良饮食生活习惯（吸烟、饮酒、辛辣生冷饮食、甜食、洗漱用具不分开、共用餐具、同住人员有HP感染或胃病史）能明显增加HP感染风险，影响根除效果，HP根除治疗少儿期比成人效果好，根除率高。

Objective To investigate and analyze the infection and eradication of Helicobacter pylori （HP） and its influencing factors for adults and children with chronic gastritis, and to provide a favorable basis for eradication therapy. Methods A total of 856 adult and 920 children with chronic gastritis were investigated by 13c-breath test in terms of infection and eradication of HP, and the self-made questionnaire was collected in terms of the common daily di- etary habits. Results The rate of HP infection among patients with chronic gastritis was 60. 75% in the adult group and it was 41.74% for the children group, and the rate of HP infection for adults were significantly higher than that of the children＇s （P〈0. 01 ） . The following aspects of the HP positive patients of the two groups were higher than that of the HP negative patients （P〈0.05）, namely sharing the same tableware and toiletries and living with family suffering from HP infection and gastric history and smoking, drinking, spicy food for adults, and sweet, raw food for children. The rate of adverse lifestyle of the adult group was significantly higher than that of the children group （P〈0. 01 ） in terms of sharing tableware, smoking, drinking, enjoying spicy diet among the HP positive patients with strict compliance of the doctors HP eradication rate： 69.84% for adult group and 86. 20% for children group, adult group were significantly lower than that of the children group （P〈0.01） . Conclusions The rate of HP infection of the adult group is signifi- cantly higher than that of the children group among the patients with chronic gastritis. Common bad diet habits （ smok- ing, drinking, cold and spicy food, sweets, sharing toiletries, sharing tableware and living with persons with HP infec- tion and gastric history） can significantly increase the risk of HP infection, affecting the eradication effect. HP eradica- tion treatment for children is better than of the adult, and the eradication rate is high.