不同浓度配置比例应用于静脉输注盐酸左氧氟沙星所致静脉炎的临床观察

Clinical observation of different concentration allocation ratios applied to phlebitiscaused by levofloxacin hydrochloride by intravenous infusion

目的探讨不同浓度配置比例应用于静脉输注盐酸左氧氟沙星所致静脉炎的情况。方法采用前瞻性研究将400例静脉输注盐酸左氧氟沙星的患者，根据医生处方开出不同浓度比例配置药液分成观察组（100例）、对照组1（100例）、对照组2（100例）、对照组3（100例），4组患者均采用0．3g盐酸左氧氟沙星药物和0．9％NaCl溶液进行配置药液，观察组及对照组1、2、3组的药液浓度配置比例分别为：0．1g：50ml、0．1g：75ml、0．1g：100ml、0．1g：125ml，观察4组患者静脉炎发生情况。结果观察组分别与对照组1、对照组2、对照组3两组之间进行比较，结果分别是x2=4．35，P〈0．05;x2=7．04，P〈0．01;x2=23．95，P〈0．01，差异均具有统计学意义。结论采用0．1g：50ml的浓度配置比例可以有效预防或减少盐酸左氧氟沙星静脉输注产生静脉炎的发生率。

Objective To investigate the condition of different concentration allocation ratios applied to phle- bitis caused by levofloxacin hydrochloride by intravenous infusion. Methods Prospective study was conducted to 400 patients with levofloxaein hydrochloride by intravenous infusion. According to doctor＇s prescription, liquid medicines at different concentration ratios were made and divided into observation group （100 cases）, control group 1 （100 cases）, control group 2 （100 cases） and control group 3 （100 cases）. 0. 3 g levofloxacin hydrochloride and 0. 9% NaC1 solu- tion were used to prepare liquid medicine for the patients in 4 groups. The liquid medicine concentration allocation ratios of observation and control groups 1, 2 and3 were0.1 g ： 50 ml, 0.1 g ： 75 ml, 0.1 g： 100 ml, 0.1 g ： 125 ml. The occurrence of phlebitis of patients in 4 groups was observed. Results Observation group was compared with control groups 1, 2 and 3. The result was X2 = 4.35, P〈0. 05 ; X2 = 7.04, P〈0. 05 ; X2 = 23.95, P〈0. 01, both differences were statistically significant. Conclusion The concentration allocation ratio of 0. 1 g： 50 ml can effectively prevent or reduce the occurrence rate of phlebitis caused by levofloxacin hydrochloride by intravenous infusion.