以熄风法为例的缺血性中风方证相应疗效分析

Analysis of the therapeutic effect of prescription-syndrome corresponding treatment on ischemic stroke with wind-extinguishing method as an example

目的探讨缺血性中风急性期方证相应使用熄风法对神经功能缺损的影响。方法运用随机、盲法、平行对照的研究方法,将201例中医辨证风痰阻络证的缺血性中风急性期患者随机分为试验组102例和对照组99例,试验组给予化痰通络汤颗粒剂加丹参、红花模拟剂,对照组给予丹参、红花颗粒剂加化痰通络汤模拟剂,2组疗程均为28天。比较组间NIHSS减分值以及证候要素评分的差异。结果 28天时点,试验组NIHSS减分值高于对照组,差异有统计学意义(P<0.05),内风证候要素评分低于对照组,差异有统计学意义(P<0.05)。结论缺血性中风急性期方证相应使用熄风法,在改善神经功能缺损方面较单纯使用活血化瘀法更有效。

Objective To explore the effect of prescription-syndrome corresponding treatment with wind-extinguishing method on neurological function defect in the acute stage of ischemic stroke. Methods 201 cases with syndrome of wind-phlegm obstructing collaterals were divided into the experiment group of 102 cases and the control group of 99 cases according to the method of random,blind and parallel controlled study. The experiment group was given Huatan Tongluo Tang Granules plus Danshen placebo,Honghua placebo,and the control group was given Danshen,Honghua plus Huatan Tongluo Tang placebo. The courses of treatment of both groups were 28 days. The differences of NIHSS reduction scores and syndrome factor scores were compared between the two groups. Results NIHSS reduction scores of the experiment group were higher than that of the control group,and the difference was statistically significant（ P〈 0. 05） and interior wind syndrome factor score was lowered than that of the control group and the difference showed statistical significance on 28 day（ P〈 0. 05）. Conclusion The prescription-syndrome corresponding treatment with windextinguishing method in the acute stage of ischemic stroke is superior to blood circulation promoting and blood stasis removing method in improving the neurological deficits.