表柔比星联合紫杉醇脂质体的新辅助化疗方法治疗三阴性乳腺癌的效果

Effects of the neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel in the treatment of triple negative breast cancer

目的 探讨表柔比星联合紫杉醇脂质体的新辅助化疗方法治疗三阴性乳腺癌的临床效果。方法 选取2015年6月-2016年6月我院收治的80例三阴性乳腺癌患者作为研究对象,随机分为观察组和对照组,各40例。对照组单独给予表柔比星新辅助化疗,观察组采用紫杉醇脂质体、表柔比星联合新辅助化疗。比较两组治疗前后的肿瘤直径、乳腺癌易感基因（BRCA1）水平、叉头框蛋白A1（FOXA1）水平、临床疗效及治疗过程中的不良反应发生率。结果 观察组的总有效率为82.50%,显著高于对照组的70.00%,差异有统计学意义（P〈0.05）。两组的不良反应发生率比较,差异无统计学意义（P〉0.05）。两组治疗后的肿瘤直径、BRCA1和FOXA1水平均低于治疗前,差异有统计学意义（P〈0.05）。观察组治疗后的肿瘤直径、BRCA1和FOXA1水平显著优于对照组治疗后,差异有统计学意义（P〈0.05）。结论 采用紫杉醇脂质体、表柔比星联合新辅助化疗治疗三阴性乳腺癌安全可靠,不增加不良反应,患者的耐受性较好,具有较高的临床应用价值。

Objective To explore the clinical efficacy of the neoadjuvant chemotherapy of the combination application of Epirubiein and Lipid Paclitaxel in the treatment of triple negative breast cancer （TNBC）.Methods 80 patients with TNBC in our hospital from June 2015 to June 2016 were selected and randomly divided into the observation group and the control group,40 cases in each group.The control group was given simple neoadjuvant chemotherapy of Epirubicin. The observation group was given neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paclitaxel.The tumor diameter,breast cancer susceptibility gene （BRCA1） level,fork-box protein A1 （FOXA1） level before and after treatment and clinical efficacy,the incidence rate of adverse reaction were compared between the two groups. Results The total effective rate of the observation group was 82.50% ,which was higher than 70.00% of the control group,with significant difference （P〈0.05）.There was no significant difference in the incidence rate of adverse reaction between the two groups （P〉0.05）.The tumor diameter,the level of BRCA1 and FOXA1 after treatment in the two group was lower than that before treatment,with significant difference （P〈0.05）.The tumor diameter, the level of BRCA1 and FOxA1 after treatment in the observation group was better than that in the control group,with significant difference （P〈 0.05）.Conclusion The neoadjuvant chemotherapy of the combination application of Epirubicin and Lipid Paelitaxel in the treatment of TNBC is safe and reliable,with no increase of adverse reaction,and the patients have a higher degree of tolerance while being treated.It is highly significant in clinical application.