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苯并噻唑和溴代芳烃的C-S交叉偶联反应及其在沃替西汀合成中的应用

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摘要 以苯并噻唑和溴代芳烃为原料,在Cu I的催化下实现了二者的C-S交叉偶联反应,得到2-芳硫基苯胺产物,反应底物适用性广、收率高.偶联产物可用于抗抑郁药物沃替西汀的合成,是此药物合成的新方法.因为不使用贵重的起始原料,也不使用味道较大的苯硫酚,所以本路线成本低、环境友好。
作者 丁飞飞
出处 《化工管理》 2017年第1期206-207,共2页 Chemical Engineering Management
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