摘要
目的:探讨结肠癌组织同源盒蛋白1(Six1)和E-钙黏蛋白(E-cad)的表达和临床意义。方法:采用SP免疫组化法检测70例结肠癌组织和30例癌旁正常组织Six1、E-cad的表达情况,并分析二者与结肠癌临床病理特征的关系及结肠癌组织Six1、E-cad表达的相关性。结果:结肠癌组织Six1的阳性表达率明显高于癌旁正常组织(P<0.01),E-cad的阳性表达率明显低于癌旁正常组织(P<0.01)。结肠癌组织Six1、E-cad表达与性别、年龄、肿瘤大小、分化程度无关(P>0.05);与TNM分期和浸润深度有关(P<0.05)。结肠癌组织Six1、E-cad表达呈负相关关系(r=-0.480,P<0.01)。结论:Six1、E-cad可能共同参与了结肠癌的发生发展过程,且二者的表达情况与结肠癌患者的不良预后密切相关。
Objective： To investigate the expression and clinical significance of Six1 and E-cad in colon cancer. Methods： SP immunohistochemical method was used to detect Six1 and E-cad expression in 70 cases of colon cancer and 30 cases ofadjacent normal tissue; and the correlations between Six1, E-cad and the clinical pathological characteristics of colon cancer were also analyzed. Results： The positive expression rate of Six1 in colon cancer was obviously higher than adjacent normal tissue, but the positive expression rate of E-cad was obviously lower（P〈0. 01）. The Six1 and E-cad expression in colon cancer was not related to sex, age, size of tumour and differentiation degree（P〉0. 05）; But related to TNM stage and infiltration depth（P〈0. 05）. The expression of Six1 in colon cancer was negative correlated to E-cad expression（r =-0.480, P〈0. 01）. Conclusions： E-cad and Six1 maybe involved in development of colon cancer together; Moreover, E-cad and Six1 expression is closely related to poor prognosis of colon cancer.
出处
《承德医学院学报》
2017年第1期3-5,共3页
Journal of Chengde Medical University
