LEEP刀联合咪喹莫特乳膏治疗外阴尖锐湿疣69例疗效观察

CLINICAL EFFECTS FOR TREATING CONDYLOMA ACUMINATUM OF VULVA WITH LEEP KNIFE COMBINED WITH IMIQUIMOD CREAM OF 69 CASES

目的:探讨高频电波刀(LEEP刀)联合咪喹莫特乳膏治疗外阴尖锐湿疣的疗效。方法:138例外阴尖锐湿疣患者随机分为观察组和对照组,每组69例,对照组采用LEEP刀治疗,观察组采用LEEP刀联合咪喹莫特乳膏治疗,比较两组患者治疗4周时、8周时的总有效率,复发率和不良反应发生率。结果:两组患者治疗8周时的总有效率均明显高于治疗4周时(P<0.05);观察组患者治疗4周时、8周时的总有效率均明显高于对照组(P<0.05)。观察组患者复发率、不良反应发生率分别为8.7%(6/69)、60.9%(42/69),均明显低于对照组(P<0.05)。结论:LEEP刀联合咪喹莫特乳膏治疗外阴尖锐湿疣具有临床疗效好、复发率低、不良反应少等优点,值得在临床上推广应用。

Objective： To investigate the curative effects for treating condyloma acuminatum of vulva with LEEP knife combined with imiquimod cream. Methods： 138 cases condyloma acuminatum of vulva patients were randomly divided into observation group and control group with 69 cases in each group. The patients in control group were treated with LEEP knife, the patients in observation group were treated with LEEP knife combined with imiquimod cream. The total effective rate 4-week and 8-week after treatment, as well as recurrence rate and adverse effects rate of 2 groups were compared. Results： The total effective rate 8-week after treatment of patients in 2 group was all significantly higher than 4-week after treatment（P〈0. 05）; while the total effective rate 4-week and 8-week after treatment of patients in observation group were all significantly higher than control group（P〈0. 05）. The recurrence rate and adverse effects rate of patients in observation group were respectively 8.7%（6/69） and 60.9%（42/69）, which were obviously lower than that of control group（P〈0. 05）. Conclusions： Treating condyloma acuminatum of vulva with LEEP knife combined with imiquimod cream has the advantages of good clinical efficacy, low recurrence rate and less adverse effects, so it is worthy of application in clinic.