脉冲射频联合阿霉素治疗原发性三叉神经痛临床疗效观察

CLINICAL EFFICACY OF TREATING IDIOPATHIC TRIGEMINAL NEURALGIA WITH PULSED RADIOFREQUENCY COMBINED ADRIAMYCIN

目的:探讨脉冲射频联合阿霉素治疗原发性三叉神经痛的疗效和安全性。方法:90例原发性三叉神经痛经保守治疗无效的患者随机分为三组(n=30),单纯阿霉素组(ADM组)、脉冲射频联合阿霉素组(PRF+ADM组)和单纯脉冲射频组(PRF组),比较三组患者的VAS评分、PRI总分、治疗有效率和并发症情况。结果:治疗后各时间点PRF+ADM组VAS评分、PRI总分明显低于PRF组,治疗有效率明显高于PRF组(P<0.05)。术后1d、3d PRF+ADM组各指标与ADM组比较,差异有统计学意义(P<0.05);其它各时间点两组各观察指标比较,差异无统计学意义。三组患者均未出现明显并发症。结论:PRF联合ADM治疗三叉神经痛近、远期疗效均较好,且安全性高,值得临床推广应用。

Objective： To investigate the efficacy and safety of treating idiopathic trigeminal neuralgia with pulsed radiofrequency combined adriamycin. Methods：90 idiopathic trigeminal neuralgia patients failed to conservative treatment were randomly divided into adriamycin（ADM） group, pulsed radiofrequency combined adriamycin（PRF＋ADM） group and PRF group with 30 patients in each group.The VAS score,PRI score,effective rate and complications of patients in 3 groups were compared. Results：The VAS score, PRI score of patients in PRF＋ADM were obviously lower than that of patients in PRF group at each time point after treatment,but the effective rate was obviously higher（P〈0. 05）. The VAS score, PRI score and effective rate had statistical difference between PRF＋ADM group and ADM group 1d and 3d after treatment（P〈0. 05）;There had no statistical significance of VAS score, PRI score and effective rate between PRF＋ADM group and ADM group at other time point after treatment. There were no obvious complications in 3 groups. Conclusions：Treating idiopathic trigeminal neuralgia with pulsed radiofrequency combined adriamycin can get better short-term and long term effects, as well as higher security, so it is worthy of clinical application.