冠心病合并亚临床甲状腺功能减退症患者与超敏C-反应蛋白及颈动脉中值厚度的相关性研究

Correlative study of coronary heart disease combining subclinical hypothyroidism with high sensitivity C-reactive protein and inti ma-media thickness

目的探讨冠心病合并亚临床甲状腺功能减退症患者的甲状腺功能与超敏C-反应蛋白(hs-CRP)、颈动脉中值厚度(IMT)的相关性。方法选择2014年9月-2015年6月在本院心内科住院或门诊就诊已确诊的冠心病患者及合并未经治疗的亚临床甲状腺功能减退症患者108例,其中冠心病合并亚临床甲状腺功能减退症患者58例,单纯冠心病患者50例。分别测定TSH、FT3、FT4、FIB、TG、TC及IMT和hs-CRP。结果冠心病合并亚临床甲状腺功能减退症组较冠心病组TG、TC、hs-CRP、IMT升高,差异均有统计学意义(P<0.05)。TSH与TC、TG、hs-CRP、IMT呈正相关(r值分别为0.276、0.309、0.397、0.391,P<0.05),而与LDL-C及HDL-C无明显相关性(P>0.05)。结论通过测定超敏-C反应蛋白、颈动脉中值厚度水平及促甲状腺激素可能对冠心病患者发生亚临床甲状腺功能减退症的诊断及治疗起到辅助作用。

Objective To discuss the correlation of thyroid function with high sensitivity C-reactive protein（ hs-CRP）,inti ma-media thickness（ IMT） in coronary heart disease patients with subclinical hypothyroidism. Methods 108 inpatients and outpatients in Department of Cardiology in this hospital were selected from September 2014 to June 2015,who were diagnosed with coronary heart disease and subclinical hypothyroidism without accepting treatment,including 50 patients only with coronary heart disease,and 58 coronary heart disease patients with subclinical hypothyroidism. TSH,FT3,FT4,FIB,TG,TC,IMT and hs-CRP were determined. Results TG,TC,hs-CRP and IMT of coronary heart disease patients with subclinical hypothyroidism were higher than that in patients with coronary heart disease only,and the difference were all statistically significant（ P 0. 05）. TSH was positively correlated with TC,TG,hs-CRP,IMT（ r = 0. 276,0. 309,0. 397,0. 391 respectively,P 0. 05）,but had no significant correlation with LDL-C and HDL-C（ P 0. 05）. Conclusion Determination of hs-CRP,IMT and thyroid stimulating hormone may play a supporting role in the diagnosis and treatment of subclinical hypothyroidism in patients with coronary heart disease.