肌注咪达唑仑治疗儿童惊厥性癲痫持续状态的临床观察

Intramuscular Midazolam in treating convulsive status epilepticus in children clinical observation

目的探讨未能及时建立静脉通道情况下,儿童惊厥性癫痫持续状态的快速有效控制方法。方法选取1岁~8岁发生惊厥性癫痫持续状态的儿童65例,能快速建立静脉通道的为对照组33例,给予地西泮注射液静脉注射治疗;反之为治疗组32例,给予咪达唑仑肌注治疗,对比2组的控制时间及有效率。结果在控制发作时间及有效率上比较,2组比较差异无统计学意义（P〉0.05）。结论肌注咪达唑仑作为抢救惊厥性癫痫持续状态一线药物选择,与地西泮相比其优越性仍需要更多高质量多中心大样本随机对照临床试验加以验证。

Objective to investigate the failed to timely establishment of intravenous access cases,rapid and effective control of convulsive status epilepticus in children. Methods Select age of 1-8 years,convulsive status epilepticus in children in 65 cases,To quickly establish intravenous access for 33 patients in the control group given intravenous diazepam injection the treatment and vice versa for the treatment of 32 cases of giving intramuscular Midazolam in the treatment,compared two groups of control over time and efficiency. Results Control time and efficiency,no statistically significant difference between the two sets of data. Conclusion Intramuscular Midazolam rescue convulsive status epilepticus as first-line drug of choice,its advantages compared with diazepam still needs more quality multi-center big sample randomized clinical trials to be verified.