甲状腺乳头状癌相关基因的研究进展

Advances in the study of genes associated with papillary thyroid carcinoma

甲状腺癌是最常见的内分泌器官的恶性肿瘤。其中甲状腺癌乳头状癌大约占90%。虽然大部分甲状腺乳头状癌的诊断和治疗没有很大的困难,但是部分仍存在挑战。随着对甲状腺乳头状癌的基因和生物学特征的了解以及新的靶向治疗的发展,对其的诊断和治疗有了进一步的发展。本文就最近有关甲状腺乳头状癌的基因的相关进展以及它们对肿瘤进展的重要意义进行系统综述。

Thyroid carcinoma is the most common malignant tumor of endocrine organs. Papillary thyroid carcinoma accounts for approximately 90% of thyroid cancers. While most tumors can be diagnosed and treated without much difficulty,a few tumors,sometimes still pose some diagnostic or therapeutic challenges. Advances in the understanding of the genetic and biologic characteristics of thyroid papillary cancer,coupled with the development of new molecular targeted therapeutics,have led to the improved diagnosis and treatment of patients with this cancer. In the current review,we summarize recent research on genetic characteristics of the thyroid papillary cancer and their importance for the development of tumor.