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Synthesis,Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole 被引量:3

Synthesis,Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
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摘要 The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole(C_(14)H_(10)FN_3OS) was synthesized,and its structure was confirmed by ~1H NMR,MS,elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system,space group P21/n with a = 11.541(16),b = 8.226(12),c = 13.683(19) ?,β = 94.872(17)o,V = 1294(3) ?~3,Z = 4 and R = 0.0648 for 2198 observed reflections with I 〉 2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%. The title compound 2-((2-fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole(C_(14)H_(10)FN_3OS) was synthesized,and its structure was confirmed by ~1H NMR,MS,elemental analyses and X-ray diffraction. It crystallizes in the monoclinic system,space group P21/n with a = 11.541(16),b = 8.226(12),c = 13.683(19) ?,β = 94.872(17)o,V = 1294(3) ?~3,Z = 4 and R = 0.0648 for 2198 observed reflections with I 〉 2σ(I). The preliminary biological test shows that the title compound has good activity against Pythium ultimum with inhibitory to be 100%.
出处 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 2016年第12期1855-1859,共5页 结构化学(英文)
基金 funded by the Natural Science Foundation of Zhejiang Province(No.LY16C140007) the program of Science and Technology of Jiangsu Province(BY2014108-14)
关键词 oxadiazole compound synthesis crystal structure antifungal activity oxadiazole compound synthesis crystal structure antifungal activity
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