冠心病患者动脉粥样硬化与人巨细胞病毒检测结果的相关性分析

Analysis of Human Cytomegalovirus in Patients with Atherosclerosis

目的观察人巨细胞病毒(HCMV)在冠心病患者动脉粥样硬化发病过程的相关性。方法选取我院2014年8月至2016年4月心内科收治的动脉粥样硬化患者136例为观察对象,其中冠心病(CHD)患者103例,非CHD患者33例。使用多普勒超声对颈动脉内膜—中层厚度(IMT)进行监测,酶联免疫吸附试验法对血清HCMV-Ig M进行检测。结果HCMV感染组心肌梗死发生几率明显高于非HCMV感染组。HCMV感染组冠状动脉多支病变的发生几率亦显著高于非HCMV感染组。病变过程中HCMV感染和患者颈动脉IMT的相关性发现:HCMV感染患者颈动脉IMT(1.31±0.27)mm,非HCMV感染(1.14±0.22)mm,P<0.05,差异有统计学意义;HCMV感染组的MMP-9以及软斑组织水平明显高于非HCMV感染组。将HCMV感染作因变量,将其他因素作自变量,筛选出3个影响因素,即:颈动脉IMT、MMP-9、软斑组织。结论冠心病动脉粥样硬化与HCMV感染呈正相关,作为其影响因素可能会增加HCMV感染的几率。

Objective To observe a pathogenic role of human cytomegalovirus（ HCMV） in patients with atherosclerosis,and to study the related clinical effects. Methods We enrolled 136 patients who were admitted to the Department of Cardiology of atherosclerosis of our hospital from August 2014 to April 2016 as the observation group,103 patients with coronary heart disease（ CHD） and 33 cases of non CHD. Doppler ultrasound monitoring was used for carotid artery intima media thickness（ IMT）. Ig Menzyme linked immunosorbent assay method was used to detect the serum HCMV. Results HCMV infection Myocardial infarction incidence in patients with HCMV infection was significantly higher than that of patient without HCMV infection. Multivessel disease incidence in patients with HCMV infection was significantly higher than that of patients without HCMV infection. Analysis of the correlation between HCMV infection and IMT in patients with carotid artery atherosclerosis showed that IMT with HCMV infection was（ 1. 31 ± 0. 27） mm.Carotid atherosclerosis in patients with IMT without HCMV infection was（ 1. 14 ± 0. 22） mm,the difference was statistically significant（ P〈0. 05）. MMP-9 and soft plaque tissue was higher in HCMV group than that of non-HCMV infection group. Conclusion Coronary artery disease and HCMV infection were positively correlated. As its influencing factors,atherosclerosis may also increase the risk of HCMV infection.