2Torres V E, Harris P C, Pirson Y. Autosomal dominant polycystic kidney disease [ J ]. Lancet, 2007,369 ( 9569 ) : 1287 - 301.
3Wilson S J,Amsler K, Hyink D P, et al. Inhibition of HER-2 ( neu/ ErbB2) restores normal function and structure to polycystic kidney disease (PKD) epithelia [ J ]. Biochim Biophys Acta, 2006,1762 (7) :647 -55.
4Sweeney W E Jr,yon Vigier R O,Frost P,Avner E D. Src inhibition ameliorates polycystic kidney disease [ J ]. J Am Soc Nephrol , 2008,19(7) :1331 -41.
5Omori S, Hida M, Fujita H, et al. Extracellular signal-regulated kinase inhibition slows disease progression in mice with polycystic kidney disease[J]. J Am Soc Nephrol,2006,17(6) :1604 - 14.
6Berthier C C,Wahl P R,Le Hir M,et al. Sirolimus ameliorates the enhanced expression of metalloproteinases in a rat model of autosomal dominant polycystic kidney disease [ J ]. Nephrol Dial Transplant,2008,23(3) :880 -9.
7Yamaguchi T, Hempson S J, Reif G A, et al. Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells [ J ]. J Am Soc Nephrol,2006,17 ( 1 ) : 178 - 87.
8Park J Y, Schutzer W E, Lindsley J N, et al. p21 is decreased in polycystic kidney disease and leads to increased epithelial cell cycle progression : roscovitine augments p21 levels [ J ]. BMC Nephrol, 2007,8:12.
9Bukanov N O, Smith L A, Klinger K W, et al. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine [ J ]. Nature,2006,444 (7121 ) :949 - 52.
10Tao Y, Kim J, Faubel S, et al. Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease [ J ]. PNAS ,2005 ,102 ( 19 ) :6954 - 9.