慢性阻塞性肺疾病气道重塑机制及其研究进展

Mechanism and advance of airway remolding in chronic obstructive pulmonary disease

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)是全球性的健康问题,以不完全可逆且进行性加重的气流受限为特征。气流受限与结构上病变分不开,气道重塑是气道壁及肺实质的慢性炎症和结构破坏。支气管壁中成分的变化,引起气道腔变狭窄扭曲,肺气肿形成,导致的结果则是气流阻力增加、进行性加重的小气道气流受限,慢性的气流阻塞。本文就COPD气道重塑机制和研究现状进行综述。

Chronic obstructive pulmonary disease （COPD） is a global health problem that characterized by progressed and not fully reversible air flow limitation. Persistent air flow limitation is closely related with structural change. Airway remolding is inflammation and structural damage of airway wall and lung parenchyma. The airway wall component become different, airway lumen become distorted narrow, emphysema formation. Thus, the air resistance increase, progressively limit the air flow. Here, we review the mechanism of COPD airway remolding and summarized the research status.