耐药结核病的现状与治疗策略

Research status and treatment strategy of drug-resistant tuberculosis

结核病是全世界重大公共卫生问题之一,严重威胁着人类健康和生命安全。随着人口流动性增大、抗结核药物使用不规范,耐药结核所占比例逐年增加。面对耐药结核患者充满了挑战,临床表现复杂多变,往往症状较轻,主要依靠结核分枝杆菌药物敏感试验诊断,给临床诊断带来很大难度。由于抗结核药物选择有限,而且需同时使用多种药物联合化疗,疗程较长,病人依从性较差,一旦出现广泛耐药结核病,临床治疗就显得束手无策。本文就近年来耐药结核病的研究进展进行综述。

Tuberculosis （TB） is one of the major public health problem in the world , which seriously threaten to human health and life safety. With the growing mobility of the population and using non-standard of the anti-TB drugs, the proportion of drug-resistant tuberculosis （DR-TB） increases year by year. Doctor face to the patients with DR-TB is full of challenges, because of the complicated clinical manifestation and the light symptom. DR-TB mainly relies on drug sensitivity test which brings great difficulty to clinical diagnosis. Once it becomes extensively-resistant tuberculosis （XDR-TB）, clinical treatments will seem helpless. This article reviewed the progress in the study of DR-TB in recent years.