维持性血液透析患者焦虑、抑郁状态与血清中IL-8、IL-17、1L-1β和hs-CRP水平的关系

The relationship between the states of anxiety as well depression of maintenance hemodialysis patients and their levels of IL8,IL-17,IL-1β and hs-CRP in serum

目的观察维持性血液透析(MHD)患者不同焦虑抑郁状态与血清中白细胞介素-8(1L-8)、IL-17、1L-1β、超敏-C反应蛋白(hs-CRP)含量水平的关系。方法采用Zung焦虑自评量表(SAS)、Zung抑郁自评量表(SDS)对120例MHD患者进行焦虑、抑郁状况评价,并于焦虑、抑郁状况评价分析第2天清晨空腹抽静脉血4 ml采用ELISA、免疫荧光干式定量法检测血清中IL-8、IL-17、1L-1β、hs-CRP含量水平。结果 MHD患者SAS、SDS评分指数越高血清中IL-8、IL-17、1L-1β、hs-CRP含量水平越高(P<0.05,P<0.01)。结论对血清中IL-8、IL-17、1L-1β、hs-CRP含量水平进行监测,可为MHD者焦虑、抑郁情绪产生及程度的预判提供理论依据。

Objective To observe the relationship between the different states of anxiety as well depression of maintenance hemodialysis（MHD） patients and their levels of IL-8,IL-17,IL-1β,hs-CRP in serum. Methods The anxiety states of 120 MHD patients were evaluated by using Zung selfrating anxiety scale（SAS）,and their depression were evaluated by using Zung selfrating depression scale（SDS）. In early morning of the 2nd day MHD patient’s 4 ml fasting venous blood were sampled for detecting the content of IL-8,IL-17,IL-1β,hs-CRP in serum by using ELISA and immunofluorescence dry quantitative method so as to analyze and evaluate the relationship between the MHD patient’s different states of anxiety and the levels of above factors in serum.Results The higher the score index on the SAS and SDS of the MHD patients were higher the levels of IL-8,IL-17,IL-1β,hs-CRP in serum were（P〈0.05 or P〈0.01）. Conclusion The monitoring IL-8,IL-17,IL-1β,hs-CRP in serum can provide the theory basis for preevaluating MHD patients’ s anxious degree.