阿糖腺苷联合病毒唑治疗手足口病患儿的疗效分析

Curative effect analysis of Vidarabine combined with Ribavirin in treatment of hand,foot and mouth disease

目的：分析阿糖腺苷联合病毒唑治疗手足口病患儿的疗效。方法：将符合诊断标准的88例手足口病患儿随机为治疗组和对照组,每组各44例。治疗组患儿给予静脉滴注阿糖腺苷（5~10 mg/kg,1次/d）和病毒唑注射液（10 mg/kg,1次/d）治疗;对照组患儿仅给予静脉滴注病毒唑注射液（10 mg/kg,1次/d）治疗。在治疗过程中,两组患儿常规给予液体疗法及对症处理;若患儿合并细菌感染则给予抗生素治疗。两组患儿均在治疗5 d后,观察并比较临床治疗效果。结果：治疗组患儿的疗效明显优于对照组,差异有统计学意义（P〈0.05）。结论：阿糖腺苷联合病毒唑治疗小儿手足口病的疗效可靠,安全,值得临床推广。

Objective： To analyze the curative effects of Vidarabine combined with Ribavirin in treatment of hand,foot and mouth disease. Methods： 88 children with hand,foot and mouth disease conforming to the diagnostic criteria were randomly divided into treatment group（ n = 44） and control group（ n = 44）. The treatment group was intravenously dripped with Vidarabine（ 5-10 mg / kg,1 / d）,and Ribavirin injection（ 10 mg / kg,1 / d）,while the control group was only give the intravenous drip of Ribavirin injection（ 10 mg / kg,1 / d）. Besides,the two groups were given the regular fluid therapy and symptomatic treatment. When the bacterial infections occurred,it should use the antibiotics. 5 days after the treatment,the clinical effects of the two groups were observed. Results： There were statistically significant differences in the curative effects between the two groups（ P 〈0. 0）. Conclusions： Vidarabine combined with Ribavirin in the treatment of the children with hand,foot and mouth disease has reliable curative effects,and is safe and worthy of clinical promotion.