老年三阴性乳腺癌组织GST-π表达与临床病理的关系

The relationship between clinicopathological and GST-π expression level of triple negative breast cancer in elder woman

目的探讨GST-π在老年三阴性乳腺癌(TNBC)组织中的表达情况及临床意义。方法收集99例非特殊型浸润性癌的TNBC标本,其中年龄≥60岁(老年组)55例,年龄<60岁(非老年组)44例。采用免疫组织化学SP法检测GST-π、Top-Ⅱ和Ki-67的蛋白表达情况,分析GST-π表达与年龄、原发肿瘤大小、腋窝淋巴结转移及病理分级等的相关性,以及与Ki-67、Top-II表达的关系。结果 TNBC患者中,50例为GST-π阳性,49例阴性;GST-π阳性率在老年组(63.64%)明显高于非老年组的阳性率(34.09%)(P<0.05);在TNBC组织中病理分级为高-中分化的GST-π阳性表达率显著性高于低分化者(P<0.05);老年组TNBC组织中GST-π阳性表达在Ki67表达时显著性高于阴性者(P<0.05);非老年组TNBC中,GST-π阳性表达率在Top-II阳性表达时明显低于Top-II阴性者(P<0.05)。结论老年TNBC患者可能对GST-π相关化疗药耐药性更强,癌组织增殖活性越高者耐药性也更强,预后更差,检测GST-π表达对指导TNBC患者治疗有一定的参考意义。

Objective To investigate the correlations between the expression level of GST -π and clinicopathology in triple negative breast cancer （TNBC） in elder women. Methods Clinieopathologieal datas of 99 cases with TNBC were obtained. The age of 55 cases were more than 60 years as old elder group, and 44 eases were less than 60 years old as non - elder group. The immunohisto- chemical SP method was used to detect the protein expression of GST -π,Top - Ⅱ and Ki -67 in TNBC. The correlation of GST -π ex- pression with age,the size of tumor,the metastasis of axillary lymph nodes and pathological grade of TNBC was analyzed, our study also analyzed the relationship between GST - π expression and expression of Ki - 67 and Top - Ⅱ. Results In this study,there were 50 cases showed positive expression of GST -π, while 49 cases showed negative expression of GST -π. Comparing with non - elder group （ 34.09% ）, the GST - π expression in elder group （ 63.64% ） was significantly higher （ P 〈 0.05 ） ; GST -π expression obviously in- creased in pathological grade Ⅰ- Ⅰ than that in grade Ⅲ （ P 〈 0.05 ）. In elder TNBC groups, there was positive correlation and statisti- cal difference between GST- π expression and Ki -67 expression （P 〈 0.05 ）. In non -elder TNBC group, the positive rate of GST -π in TOP - II positive expression group was significantly lower than that in the TOP - Ⅱ negative group （ P 〈 0.05）. Conclusion （;ST -π- re- lated chemotherapeutic agents are more resistant in eider group with TNBC than that in non -elder group. The higher the proliferative activity and the higher is drug resistance and the worse is the prognosis. There is potential value to guide the therapy for TNBC patients through detec- ting GST-π expression.