和肽素和糖化血红蛋白水平在2型糖尿病合并急性冠脉综合征患者中的作用研究

Study of copeptin and glycosylated hemoglobin in acute coronary syndromes for patients with type 2 diabetes mellitus

目的探讨和肽素(Copeptin)和糖化血红蛋白(Hb A1C)与2型糖尿病合并急性冠脉综合征患者的关系。方法 183例冠状动脉(冠脉)造影证实至少一支血管狭窄≥70%的2型糖尿病患者,其中120例稳定性心绞痛(SAP组),63例为急性冠脉综合征患者(ACS组)。选择64例单纯糖尿病患者作为单纯糖尿病组。采用高效液相色谱法检测Hb Al C,和肽素用竞争性酶联免疫吸附法(ELISA)单纯糖尿病组方法测定。结果 ACS组较单纯性糖尿病组和肽素[(0.77±0.03)ng/m L比(0.34±0.03)ng/m L]及Hb A1C[(8.27±0.08)%比(7.25±0.02)%]显著增高(P<0.05);与SAP组和肽素[(0.77±0.03)比(0.56±0.01)ng/m L]及Hb A1C[(8.27±0.08)比(7.70±0.05)%]比较亦明显升高(P<0.05);随冠脉病变血管支数增加,和肽素显著增高而糖化血红蛋白无明显变化(P<0.05)。结论和肽素与Hb A1C在2型糖尿病合并急性冠脉综合征患者发病中具有重要作用。

Objective e To explore the association of copeptin and HbA1 c levels with acute coronary syndromes （ACS） in pa- tients with type 2 diabetes mellitus. Methods Among 183 consecutive patients with coronary heart disease （ ≥70% stenosis） and type2 diabetes mellitus, 120 cases had stable angina （Group I）,63 cases were ACS （Group II）. Another 64 patients with pure diabetes were served as a control group. Serum levels of copeptin were measured using ILISA methods. Results Copeptin and HbAlc levels were sig- nificantly higher in Group I than that of the control group copeptin [ （0.77 ± 0.03） than（0.34 ± 0.03）ng/mL] and HbA1c [ （8.27 ± 0.08 ） than （7.25 ± 0.02 ） % ] （ P 〈 0.05 ）, and the stable angina group copeptin [ （ 0.77 ± 0.03 ） than （ 0.56 ± 0.01 ） ng/mL ] and HbA1c [ （8.27 ± 0.08 ） than （7.70 ± 0.05） % ] （P 〈 0.05）. Further analysis the number of diseased coronary arteries increased signifi- cantly with copeptin （P 〈 0.05） ,was not related to HbA1 c level. Conclusions Copeptin and HbA1c may play an important role in the development of acute coronary syndromes in patients with type 2 diabetes.