金属-有机骨架材料在色谱分离中的应用

Application of Metal-Organic Frameworks in Chromatographic Separation

金属-有机骨架材料(Metal-organic frameworks,MOFs),因其具有较好的热稳定性、化学稳定性、可设计性等特点,广泛应用于气体吸附、物质分离、提纯、催化等领域,同时也作为模板制备各种功能材料.MOFs作为色谱分离的材料已得到了较多的研究与应用.按照被分离物质的类别,综述和总结了不同MOFs材料作为色谱固定相的分离效果,重点介绍了MOFs材料的色谱分离机理.MOFs材料的孔径、功能基团和不饱和金属位点在分离中起到重要的作用,最后对MOFs在色谱分离应用中的问题和前景进行了分析和展望.

Metal-organic frameworks （MOFs） are synthesized via the self-assembling combination of organic ligands and inorganic metals or metal-oxo units （secondary building units, SBUs） using strong bonds to form a porous open crystalline. Because of their outstanding thermal stability, chemical stability and designability, MOFs are successfully applied in various fields, such as gas absorption, separation, purification, catalysis, as well as templates for various functional materials. MOFs are also used as column materials for gas or liquid chromatography separation. In this paper, the studies about MOFs used as stationary phases in gas chromatography and high-performance liquid chromatography were reviewed according to the sepa- rated various analytes. We summarized the separation effects of different MOFs for different substances, especially focusing on the separation mechanism of MOFs. The key influence factors on the chromatographic separation, such as pore diameter, functional groups and unsaturated metal sites of MOFs, were expounded. Then, the challenges of MOFs as stationary phases in gas and high-performance liquid chromatography were discussed, which include the mechanism, chiral separation, the limited MOFs in chromatographic separation. The future research in this field should focus on defining separation mecha- nism, improving their stability and synthesizing the MOFs with special function.