肝病患者血清胰岛素样生长因子I含量及与肝功能的关系

Relationship between Serum Insulin-like Growth Factor-I Level and Liver Function in Patients with Liver Diseases

目的 研究肝病患者血清中胰岛素样生长因子I(IGF -I)的变化及其与肝功能的关系 .方法 各型肝炎患者 113例 ,对照组 30例 ,用放射免疫法检测血清IGF -I含量 ,同时检测有关肝功能指标 .结果 急性肝炎、慢性肝炎轻度、慢性肝炎中度患者血清IGF -I含量分别为 6 37.6± 178.3ng/ml、4 5 8.6± 2 76 .4ng/ml、6 0 1.7± 2 76 .8ng/ml,明显高于对照组 316 .1± 10 9.1ng/ml (p <0 .0 0 1) .慢性肝炎重度、肝硬化患者血清IGF -I含量为 2 2 4 .5± 16 8.2ng/ml和12 0 .5± 94 .4ng/ml明显低于对照组 (p<0 .0 5 ) .IGF -I含量与部分肝功能指标相关 (p <0 .0 5 ) .结论 检测IGF -I对估计慢性肝病预后有一定的价值 .

Objective To study the relationship between Serum insulin-like growth factor-I (IGF-I) Level and liver function in patients with liver diseases. Methods Serum IGF-I and liver function indexes were measured in 113 patients with liver diseases and 30 healthy person as normal control. Results IGF-I level of acute hepatitis was 637.6±178.3 ng/ml, of mild chronic hepatitis 458.6+±276.4 ng/ml, of middle chronic hepatitis 601.7±276.8 ng/ml, All of them were significantly higher than the control group 316.1±109.1 ng/ml, (p<0.001). IGF-I level of severe chronic hepatitis was 224.5±168.2 ng/ml, of liver cirrhosis 120.5±94.4 ng/ml, Both were significantly lower than the control group (p<0.05). Serum IGF-I was correlated with some indices of liver function (p<0.05). Conclusions It is useful to detect IGF-I in evaluating the prognosis of liver diseases.