伴轻度抑郁症状的双相障碍患者执行和注意功能对照研究

A comparative study of executive and attention function in bipolar disorder patients with mild depressive symptoms

目的：探讨伴轻度抑郁症状的双相障碍患者执行功能、注意功能与健康对照者的差异。方法：40例伴轻度抑郁症状的双相障碍患者（研究组）和40名年龄、性别、受教育年限与研究组匹配的健康者（健康对照组）均采用威斯康星卡片分类测验（WCST）及持续操作测验（CPT）测试两组执行功能和注意功能。结果：两组WCST测试成绩除完成第1个分类所需应答数、非持续性错误数差异无统计学意义（P〉0.05）外,完成分类数、总应答数、正确应答数、错误应答数、持续性错误数、持续性错误率组间差异有统计学意义（t=-6.10-5.96,P均=0.000）;CPT测验中正确数研究组明显低于健康对照组（t=-3.87,P=0.000）;错误数明显高于健康对照组（t=5.21,P=0.000）。结论：伴轻度抑郁症状的双相障碍患者存在执行功能损害和注意功能损害。

Objective：To explore the differences of the executive function and attention function between patients of bipolar disorder with mild depressive symptoms and healthy controls. Method：Forty patients of bipolar disorder with mild depressive symptoms（study group）and age,sex and education year matched forty healthy controls（healthy control group）were entolled. The Wisconsin card sorting test（WCST）and the continu-ous performance test（CPT）were used to assess and compared executive function and attention function between two groups,respectively. Results：For WCST,there were no statistically differences in trials to compete first category and nonperseverative errors（P 〉 0. 05）,but statistically significant differences in number of categories completed,trials administered,total correct responses,total errors,perseverative errors,and persistent error rate be-tween two groups（t = -6. 10-5. 96,P =0. 000）. In CPT test,the correct number in study group was significantly lower than that in the healthy control group（t = - 3. 87,P = 0. 000）,while the error number in study group was significantly higher than that in the healthy control group（t = 5. 21,P = 0. 000）. Conclusion：The patients of bipolar disorder with mild depressive symptoms had impaired executive function and attention function.