血浆脂联素TNF-α和IL-6在脓毒症鉴别诊断中的意义

Clinical value of adiponectin, TNF-α and IL-6 in differential diagnosis for patients with sepsis

目的探讨血浆脂联素、肿瘤坏死因子-α（TNF—α）和白细胞介素-6（IL-6）在脓毒症和全身炎症反应综合征（SIRS）鉴别诊断中的临床意义。方法选取SIRS患者26例，脓毒症患者210例（一般脓毒症组83例、严重脓毒症组68例及感染性休克组59例），健康对照20例。比较各组患者血浆脂联素、TNF-α和IL-6差异。结果脓毒症各组血浆脂联素均显著低于SIRS组（P〈0．05）。脓毒症各组血浆TNF-α均显著高于SIRS组（P〈0．05）。脓毒症各组血浆IL-6均显著高于SIRS组（P〈0．05）。结论联合检测血浆脂联素、TNF—α和IL-6对脓毒症鉴别诊断具有一定指导意义。

Objective To evaluate the clinical value of adiponectin, tumor necrosis factor-α （TNF-α） and interleukin-6 （IL-6） in differential diagnosis for sepsis and systemic inflammatory response syndrome （SIRS）. Methods We selected 26 patients with SIRS, 210 patients with sepsis （83 cases of general sepsis group, 68 cases of severe sepsis group and 59 cases of septic shock group）, 20 cases of healthy controls. The adiponectin, TNF- α and IL- 6 of plasma were compared between the groups. Results The plasma adiponectin of sepsis groups was significantly lower than that of SIRS group （P 〈 0.05）. The plasma TNF-α of sepsis groups was significantly higher than that of SIRS group （P 〈 0.05）. The plasma IL-6 of sepsis groups were significantly higher than that of SIRS group （P 〈 0.05）. Conclusion The joint detection of plasma adiponectin, TNF-α and IL-6 has guiding significance in the early diagnosis and prognosis for sepsis.