川崎病并发冠状动脉损害的危险因素分析

Risk factors for coronary artery lesion in children with Kawasaki's disease

目的探讨川崎病发生冠状动脉损害的危险因素。方法回顾性分析127例川崎病患儿的临床资料,根据有无冠状动脉损害分为冠状动脉损害(CAL)组27例和无冠状动脉损害(NCAL)组100例。对与冠状动脉损害发生可能有关的临床资料及实验室检查进行单因素分析及多因素Logistic回归分析。结果单因素分析显示:CAL组与NCAL组患儿性别、热程、血清白蛋白比较差异有统计学意义(P<0.05);多因素Logistic回归分析显示:患儿性别、热程、血清白蛋白与冠状动脉损害的发生密切相关。结论男性患儿、发热时间延长、血清白蛋白降低是川崎病发生冠状动脉损害的危险因素。

Objective To investigate the risk factors for coronary artery lesions（ CAL） with Kawasaki＇s disease（ KD） in children. Methods The clinical data of 127 children with Kawasaki＇s disease were retrospectively analyzed. According to the children with or without CAL,patients were divided into CAL group（ 27 cases） and NCAL group（ 100 cases）. A single factor analysis and multi factor Logistic regression analysis were performed on the clinical data and laboratory data which may be related to the occurrence of CAL. Results The single factor analysis showed that gender,thermal history and serum albumin were significantly different between CAL group and NCAL group（ P〈0. 05）. Logistic regression analysis showed that gender（ P =0. 019）,fever time（ P = 0. 017）,Alb（ P = 0. 049） were closely related to the occurrence of CAL. Conclusion The risk factors of CAL in children with KD are male children,prolonged heating time and lower serum albumin.